N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

Base Information

Chemical Name:N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide
CAS No.:251456-90-3
Molecular Formula:C₂₃H₃₃N₃O₃Si
Molecular Weight:427.619
Hs Code.:

Synonyms:N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

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Chemical Property of N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

Chemical Property:

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Technology Process of N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

There total 4 articles about N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 619-84-1
p-N,N-dimethylaminobenzoic acid

: 251456-90-3
N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / TEA; BOP-Cl / CH₂Cl₂

2: 1M aq. LiOH / tetrahydrofuran / 4 h / 20 °C

3: TEA; BOP-Cl / CH₂Cl₂

With lithium hydroxide; TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/jm991091h

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 251456-90-3
N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / TEA; BOP-Cl / CH₂Cl₂

2: 1M aq. LiOH / tetrahydrofuran / 4 h / 20 °C

3: TEA; BOP-Cl / CH₂Cl₂

With lithium hydroxide; TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/jm991091h

Reference yield:

: 251456-88-9
methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate

: 251456-90-3
N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1M aq. LiOH / tetrahydrofuran / 4 h / 20 °C

2: TEA; BOP-Cl / CH₂Cl₂

With lithium hydroxide; TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; dichloromethane; 1: Hydrolysis / 2: Condensation;
DOI:10.1021/jm991091h