(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol

Base Information

• Chemical Name: (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol
• CAS No.: 143225-31-4
• Molecular Formula: C₁₉H₃₂N₂O₃
• Molecular Weight: 336.475
• Mol file: 143225-31-4.mol

Synonyms:(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol

Chemical Property of (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol

There total 8 articles about (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

isobutylamine (78-81-9) + [S-(R*,R*)]-(1-oxiranyl-2-phenylethyl)-carbamic acid 1,1-dimethylethyl ester (103127-56-6) → (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol (143225-31-4)

Guidance literature:

In isopropyl alcohol;

Reference yield: 47.0%

isobutylamine (78-81-9) + (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) → (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol (143225-31-4)

Guidance literature:

In isopropyl alcohol; at 50 ℃;

DOI:10.1016/j.bmc.2005.06.048

Reference yield:

{(1S,2S)-1-Benzyl-2-hydroxy-3-[2-methyl-prop-(E)-ylideneamino]-propyl}-carbamic acid tert-butyl ester → (2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1-(isobutylamino)-4-phenylbutan-2-ol (143225-31-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 23 ℃; for 4h;

DOI:10.1002/(SICI)1521-3773(19990712)38:13/14<1931::AID-ANIE1931>3.0.CO;2-4

upstream raw materials:

isobutylamine

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

Boc-L-phenylalaninal

(2S,3S)-N-tert-butyloxycarbonyl-2-amino-3-hydroxy-1-phenyl-4-nitrobutane

Downstream raw materials:

[(1S,2S)-1-Benzyl-2-hydroxy-3-(1-isobutyl-3-methyl-ureido)-propyl]-carbamic acid tert-butyl ester

[(1S,2S)-1-Benzyl-3-(3-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

4-amino-N-((2S,3S)-2-hydroxy-4-phenyl-3-amino-butyl)-N-isobutyl-benzenesulfonamide

C₂₆H₃₄N₄O₃