2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline

Base Information

Chemical Name:2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline
CAS No.:1618682-83-9
Molecular Formula:C₂₀H₁₆ClF₄NO₂
Molecular Weight:413.799
Hs Code.:

Synonyms:2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline

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Chemical Property of 2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline

Chemical Property:

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Technology Process of 2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline

There total 2 articles about 2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1618682-93-1
5-chloro-8-methoxyquinoline 1-oxide

: 1206-46-8
trimethyl(pentafluorophenyl)silane

: 865-47-4
potassium tert-butylate

: 1618682-83-9
2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline

Guidance literature:: In tetrahydrofuran; at -20 ℃; for 0.666667h; regioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1039/c4ob01088d

Reference yield:

: 17012-44-1
chloro-5 methoxy-8 quinoleine

: 1618682-83-9
2-(4-(tert-butoxy)-2,3,5,6-tetrafluorophenyl)-5-chloro-8-methoxyquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / water; dichloromethane / 12 h / 0 °C / Inert atmosphere

2: tetrahydrofuran / 0.67 h / -20 °C / Molecular sieve; Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c4ob01088d