4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

Base Information

Chemical Name:4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate
CAS No.:960388-82-3
Molecular Formula:C₁₉H₁₈BrN₃O₃S₂
Molecular Weight:480.406
Hs Code.:

Synonyms:4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

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Chemical Property of 4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

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Technology Process of 4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

There total 8 articles about 4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 960388-80-1
8-(3-bromophenyl)-8-(4-hydroxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione

: 124-63-0
methanesulfonyl chloride

: 960388-82-3
4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 30 ℃;

Reference yield:

: (3-bromophenyl)(4-methoxyphenyl)methanimine

: 960388-82-3
4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 4.25 h / 0 - 20 °C

2: sodium hydrogencarbonate / dichloromethane; water / 2 h / 0 °C

3: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

4: ethanol / 1.5 h / 70 °C

5: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

6: triethylamine / dichloromethane / 30 °C

With sodium tetrahydroborate; potassium tert-butylate; boron tribromide; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 960388-74-3
8-(3-bromophenyl)-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione

: 960388-82-3
4-[8-(3-bromophenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidin-8-yl]phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

2: triethylamine / dichloromethane / 30 °C

With boron tribromide; triethylamine; In dichloromethane;