Technology Process of 3-chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-iodoquinolin-5-amine
There total 8 articles about 3-chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-iodoquinolin-5-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: iodine; lithium diisopropyl amide / tetrahydrofuran / -78 °C
2: lithium diisopropyl amide / tetrahydrofuran / -78 °C
3: nitric acid / sulfuric acid / 0 °C
4: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / Reflux
5: iron; ammonium chloride / ethanol; water / Reflux
6: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 20 °C
7: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C
With
N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); iodine; nitric acid; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; acetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; sulfuric acid; water; N,N-dimethyl-formamide; toluene;
4: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1016/j.bmcl.2012.07.047
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
2: nitric acid / sulfuric acid / 0 °C
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / Reflux
4: iron; ammonium chloride / ethanol; water / Reflux
5: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 20 °C
6: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C
With
N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); nitric acid; sodium tris(acetoxy)borohydride; iron; sodium carbonate; ammonium chloride; acetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; sulfuric acid; water; N,N-dimethyl-formamide; toluene;
3: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1016/j.bmcl.2012.07.047