N-Trityl-4-formylbutanamide

Base Information

Chemical Name:N-Trityl-4-formylbutanamide
CAS No.:132565-62-9
Molecular Formula:C₂₄H₂₃NO₂
Molecular Weight:357.452
Hs Code.:

Synonyms:N-Trityl-4-formylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Trityl-4-formylbutanamide

Chemical Property:

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Technology Process of N-Trityl-4-formylbutanamide

There total 6 articles about N-Trityl-4-formylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 5-hydroxy-N-tritylpentanamide

: 132565-62-9
N-Trityl-4-formylbutanamide

Guidance literature:: With dipyridinium dichromate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00413

Reference yield: 29.0%

: 201230-82-2
carbon monoxide

: 132565-57-2
N-Trityl-3-butenamide

: 132565-61-8
N-Trityl-4-methyl-3-pyrrolin-2-one

: 132565-62-9
N-Trityl-4-formylbutanamide

: 3-Methyl-4-oxo-N-trityl-butyramide

Guidance literature:: With hydrogen; chlorocarbonylbis(triphenylphosphine)rhodium(I); In tetrahydrofuran; at 100 ℃; for 18h; under 62057.8 Torr; Yields of byproduct given;
DOI:10.1021/jo00006a013

Reference yield:

: 1121-89-7
piperidine-2,6-dione

: 132565-62-9
N-Trityl-4-formylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 20 °C

2.1: potassium hydroxide / ethanol / 48 h / Reflux

2.2: pH 2

3.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 0 °C

3.2: 4 h / 20 °C

4.1: dipyridinium dichromate / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dipyridinium dichromate; sodium tris(acetoxy)borohydride; potassium carbonate; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.9b00413