1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

Base Information

Chemical Name:1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester
CAS No.:944282-76-2
Molecular Formula:C₂₂H₃₁F₃O₅SSi
Molecular Weight:492.632
Hs Code.:

1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

Synonyms:1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

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Chemical Property of 1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

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Technology Process of 1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

There total 6 articles about 1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 944282-75-1
(2S,4R)-2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-4-ethenylcyclopentanone

: 145100-50-1
1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide

: 944282-76-2
1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

Guidance literature:: (2S,4R)-2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-4-ethenylcyclopentanone; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 1h;

1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide; In tetrahydrofuran; toluene; at -78 ℃; for 2h; Further stages.;
DOI:10.1021/jo702635t

Reference yield:

: 944282-73-9
C₂₁H₃₄O₄Si

: 944282-76-2
1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / tetrahydrofuran / 1.5 h / 0 - 20 °C

2.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

3.1: 82 percent / SmI₂ / methanol; tetrahydrofuran / 5 h / 0 °C

4.1: potassium 1,1,1,3,3,3-hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

4.2: 92 percent / tetrahydrofuran / 2 h

With pyridine; samarium diiodide; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200700517

Reference yield:

: C₂₆H₄₂O₅Si

: 944282-76-2
1,1,1-trifluoromethanesulfonic acid (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopenten-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

2.1: 82 percent / SmI₂ / methanol; tetrahydrofuran / 5 h / 0 °C

3.1: potassium 1,1,1,3,3,3-hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

3.2: 92 percent / tetrahydrofuran / 2 h

With samarium diiodide; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200700517