(S)-2-amino-1,2,2-triphenylethanol

Base Information

• Chemical Name: (S)-2-amino-1,2,2-triphenylethanol
• CAS No.: 220088-97-1
• Molecular Formula: C₂₀H₁₉NO
• Molecular Weight: 289.377
• Mol file: 220088-97-1.mol

Synonyms:(S)-2-amino-1,2,2-triphenylethanol

Chemical Property of (S)-2-amino-1,2,2-triphenylethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-1,2,2-triphenylethanol

There total 5 articles about (S)-2-amino-1,2,2-triphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-2-azido-1,2,2-triphenylethanol (229326-81-2) → (S)-2-amino-1,2,2-triphenylethanol (220088-97-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 10h; Ambient temperature;

DOI:10.1021/jo982442n

Reference yield:

(S)-2,2,3-triphenyloxirane (157556-88-2) → (S)-2-amino-1,2,2-triphenylethanol (220088-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Ti(i-PrO)2(N₃)2, 2.) aq. H₂SO₄ / 1.) PhH, 70 deg C, 30 min, 2.) Et₂O, 1 h

2: 99 percent / H₂ / Pd/C / methanol / 10 h / Ambient temperature

With diisopropoxytitanium diazide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jo982442n

Reference yield:

(S)-4,4,5-triphenyl-1,3,2-dioxathiolane-2-oxide (51363-92-9) → (S)-2-amino-1,2,2-triphenylethanol (220088-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoromethanesulfonic acid / -10 °C

2: conc. H₂SO₄ / methanol / Heating

With trifluorormethanesulfonic acid; sulfuric acid; In methanol;

DOI:10.1002/adsc.200303178

upstream raw materials:

(S)-2-methyl-4,4,5-triphenyl-4,5-dihydrooxazole

(S)-2-azido-1,2,2-triphenylethanol

(S)-4,4,5-triphenyl-1,3,2-dioxathiolane-2-oxide

(S)-2,2,3-triphenyloxirane