Technology Process of (4E,8E)-(S)-12-Benzyloxy-8-ethyl-4,10-dimethyl-dodeca-4,8-dienoic acid
There total 9 articles about (4E,8E)-(S)-12-Benzyloxy-8-ethyl-4,10-dimethyl-dodeca-4,8-dienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
acetone;
for 4h;
Heating;
DOI:10.1021/ja00275a055
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / Mg / tetrahydrofuran / reflux, 2h than rt., 90 min
2: propionic acid / toluene / 15 h / Heating
3: 96 percent / LiAlH4 / diethyl ether / Ambient temperature
4: 80 percent / pyridinium chlorochromate, NaOAc / CH2Cl2 / 15 h
5: 80.17 percent / 1.) Mg / tetrahydrofuran / Heating
6: propionic acid / toluene / Heating
7: 3.185 g / 1 M LiOH / acetone / 4 h / Heating
With
lithium hydroxide; lithium aluminium tetrahydride; sodium acetate; magnesium; propionic acid; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/ja00275a055
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) O3; 2.) zinc (dust), acetic acid / 1.) MeOH, -78 deg C, 30 min; 2.) 2 h, rt
2: 94 percent / Mg / tetrahydrofuran / reflux, 2h than rt., 90 min
3: propionic acid / toluene / 15 h / Heating
4: 96 percent / LiAlH4 / diethyl ether / Ambient temperature
5: 80 percent / pyridinium chlorochromate, NaOAc / CH2Cl2 / 15 h
6: 80.17 percent / 1.) Mg / tetrahydrofuran / Heating
7: propionic acid / toluene / Heating
8: 3.185 g / 1 M LiOH / acetone / 4 h / Heating
With
lithium hydroxide; lithium aluminium tetrahydride; sodium acetate; ozone; magnesium; acetic acid; propionic acid; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/ja00275a055
