N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine
• CAS No.: 1508268-93-6
• Molecular Formula: C₂₅H₃₀N₂O₆
• Molecular Weight: 454.523
• Mol file: 1508268-93-6.mol

Synonyms:N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine

Chemical Property of N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine

There total 3 articles about N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-dimethylamino-benzaldehyde (100-10-7) + N-(tert-butyloxycarbonyl)-3-(3-acetyl-4-hydroxyphenyl)-L-alanine (269745-72-4) → N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine (1508268-93-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/bc400325n

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine (1508268-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / nitrobenzene

2: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium hydroxide; In ethanol; water; nitrobenzene;

DOI:10.1021/bc400325n

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → N-(tert-butoxycarbonyl)-3-(3-[4-(dimethylamino)phenyl]prop-2-enoyl)-L-tyrosine (1508268-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / nitrobenzene

2: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium hydroxide; In ethanol; water; nitrobenzene;

DOI:10.1021/bc400325n

upstream raw materials:

di-tert-butyl dicarbonate

4-dimethylamino-benzaldehyde

N-(tert-butyloxycarbonyl)-3-(3-acetyl-4-hydroxyphenyl)-L-alanine

L-tyrosine

Downstream raw materials:

N-(tert-butoxycarbonyl)-3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine

3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine hydrochloride

3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine