Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

Base Information

Chemical Name:Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate
CAS No.:1416732-75-6
Molecular Formula:C₁₈H₁₅F₄N₅O₃S
Molecular Weight:457.408
Hs Code.:

Synonyms:Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

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Chemical Property of Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

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Technology Process of Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

There total 5 articles about Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1416732-19-8,1443429-65-9
1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

: 2365-48-2
Methyl thioglycolate

: 1416732-75-6
Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

Guidance literature:: With caesium carbonate; In tetrahydrofuran; at 20 - 65 ℃; for 48h; Inert atmosphere;

Reference yield:

: 294182-28-8
5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine

: 1416732-75-6
Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 65 °C

2: caesium carbonate / tetrahydrofuran / 48 h / 20 - 65 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416732-75-6
Methyl 2-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)thio)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C

2.2: 2 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 65 °C

5.1: caesium carbonate / tetrahydrofuran / 48 h / 20 - 65 °C / Inert atmosphere

With n-butyllithium; copper; potassium carbonate; caesium carbonate; In tetrahydrofuran; diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;