ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

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Chemical Name:ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate
CAS No.:224645-98-1
Molecular Formula:C₁₈H₂₃NO₄
Molecular Weight:317.385
Hs Code.:

Synonyms:ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

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Chemical Property of ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

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Technology Process of ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

There total 2 articles about ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 224645-96-9
(E,R)-N-(3-ethoxycarbonyl-2-propenyl)-N-(1-phenylethyl)-3-oxobutanamide

: 224645-98-1
ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

: ethyl (3R,4S,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

Guidance literature:: With sodium ethanolate; In ethanol; at -78 ℃; for 1h; Yields of byproduct given;
DOI:10.1016/S0040-4020(99)00091-5

Reference yield:

: 171196-76-2
(E,R)-N-(3-ethoxycarbonyl-2-propenyl)-N-(1-phenylethyl)amine

: 224645-98-1
ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / tetrahydrofuran / 1 h / -15 °C

2: NaH / tetrahydrofuran / 1 h / -78 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0957-4166(99)00031-2

Reference yield: 74.0%

: 75-36-5
acetyl chloride

: 224645-98-1
ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate

: [(3R,4S)-4-((R)-1-Acetylamino-ethyl)-5-oxo-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-yl]-acetic acid ethyl ester

Guidance literature:: ethyl (3S,4R,1'R)-<3-acetyl-2-oxo-1-(1'-phenylethyl)pyrrolidin-4-yl>acetate; With ammonium acetate; sodium cyanoborohydride; at -15 ℃; for 12h;

acetyl chloride; With dmap; triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.tetasy.2003.08.024