2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

Base Information

Chemical Name:2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate
CAS No.:1239236-48-6
Molecular Formula:C₃₇H₃₇ClN₆O₅S₂
Molecular Weight:745.323
Hs Code.:

2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

Synonyms:2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

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Chemical Property of 2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

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Technology Process of 2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

There total 5 articles about 2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 15761-38-3
L-N-Boc-Ala

: 1239234-36-6
2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

: 1239236-48-6
2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/cmdc.201700151

Reference yield:

: 112906-84-0
2-[4-(2-hydroxyethoxy)benzylidene]malononitrile

: 1239236-48-6
2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1: tributyl-amine / methanol / 20 h / 20 °C

2: isopentyl nitrite; copper dichloride / acetonitrile / 6 h / 70 °C

3: tetrahydrofuran / 0.5 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With tributyl-amine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; copper dichloride; isopentyl nitrite; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; 1: |Hantzsch Pyridine Synthesis;
DOI:10.1002/cmdc.201700151

Reference yield:

2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile: 1163271-54-2
2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile

: 1239236-48-6
2-(4-(2-((2-(4-chlorophenyl)-1,3-thiazol-4-ylmethyl)sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy)ethyl N-(tert-butoxycarbonyl)-L-alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201700151