2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

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Chemical Name:2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile
CAS No.:1239234-36-6
Molecular Formula:C₂₉H₂₄ClN₅O₂S₂
Molecular Weight:574.127
Hs Code.:

Synonyms:2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

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Chemical Property of 2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

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Technology Process of 2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

There total 4 articles about 2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 123-75-1
pyrrolidine

2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile: 1163271-54-2
2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile

: 1239234-36-6
2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

Guidance literature:: In methanol; at 20 - 66 ℃; for 1h; Temperature; Solvent; Large scale;

Reference yield:

: 112906-84-0
2-[4-(2-hydroxyethoxy)benzylidene]malononitrile

: 1239234-36-6
2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tributyl-amine / methanol / 20 h / 20 °C

2: isopentyl nitrite; copper dichloride / acetonitrile / 6 h / 70 °C

3: tetrahydrofuran / 0.5 h / 20 °C

With tributyl-amine; copper dichloride; isopentyl nitrite; In tetrahydrofuran; methanol; acetonitrile; 1: |Hantzsch Pyridine Synthesis;
DOI:10.1002/cmdc.201700151

Reference yield:

: 2521-24-6
4-chlorothiobenzamide

: 1239234-36-6
2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-4-[4-(2-hydroxyethoxy)phenyl]-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 26 h / 20 - 55 °C

2: tributyl-amine / methanol / 20 h / 20 °C

3: isopentyl nitrite; copper dichloride / acetonitrile / 6 h / 70 °C

4: tetrahydrofuran / 0.5 h / 20 °C

With tributyl-amine; copper dichloride; isopentyl nitrite; In tetrahydrofuran; methanol; isopropyl alcohol; acetonitrile; 2: |Hantzsch Pyridine Synthesis;
DOI:10.1002/cmdc.201700151