methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

Base Information

Chemical Name:methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate
CAS No.:1206531-83-0
Molecular Formula:C₂₃H₂₆N₄O₅S
Molecular Weight:470.549
Hs Code.:

Synonyms:methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

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Technology Process of methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

There total 1 articles about methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1055889-65-0
methyl 2-(S)-tert-butoxycarbonylamino-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

: 98-09-9
benzenesulfonyl chloride

: 1206531-83-0
methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

Guidance literature:: methyl 2-(S)-tert-butoxycarbonylamino-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate; With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h;

benzenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/anie.200900206

Reference yield:

: 1206531-83-0
methyl 2-(S)-phenylsulfonamido-3-(4-(3-pyrimidin-2-ylaminopropoxy)phenyl)propionate

: methyl 2-(S)-phenylsulfonamido-3-(4-(3-(tetrahydropyrimidin-2(1H)-ylideneamino)propoxy)phenyl)propionate acetate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃; under 19001.3 Torr;
DOI:10.1002/anie.200900206