Technology Process of 4-[18F]-1,1-dimethylethyl ester benzoic acid
There total 2 articles about 4-[18F]-1,1-dimethylethyl ester benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic anhydride / tetrahydrofuran / 0 °C
1.2: 2 h / 20 °C
2.1: 1 h / 0 °C / Inert atmosphere
3.1: potassium carbonate; K[18F]-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]-hexacosane complex / dimethyl sulfoxide / 0.17 h / 120 °C
With
K[18F]-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]-hexacosane complex; potassium carbonate; trifluoroacetic anhydride;
In
tetrahydrofuran; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1 h / 0 °C / Inert atmosphere
2: potassium carbonate; K[18F]-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]-hexacosane complex / dimethyl sulfoxide / 0.17 h / 120 °C
With
K[18F]-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]-hexacosane complex; potassium carbonate;
In
dimethyl sulfoxide;
- Guidance literature:
-
4-[18F]-1,1-dimethylethyl ester benzoic acid;
With
tetrapropylammonium hydroxide;
In
water;
at 120 ℃;
for 0.0666667h;
Inert atmosphere;
With
O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
water; acetonitrile;
at 90 ℃;
for 0.0333333h;
DOI:10.1016/j.bmcl.2018.07.009
