methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Base Information

Chemical Name:methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate
CAS No.:1399845-48-7
Molecular Formula:C₃₆H₃₅N₇O₄
Molecular Weight:629.718
Hs Code.:

Synonyms:methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

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Chemical Property of methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

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Technology Process of methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

There total 11 articles about methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1399845-47-6
(R)-tert-butyl 3-(5-(4'-(2-((2S,5S)-5-(methoxycarbonylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)morpholine-4-carboxylate

: 1399845-48-7
methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 204326-24-9
(2S,11S)-11-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-12-oxo-1-azatricyclo[6.4.1.0^[4,13]]trideca-4⁽¹³⁾,5,7-triene-2-carboxylic acid

: 1399845-48-7
methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

5: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 0.25 h / 135 °C / Sealed tube; Inert atmosphere; Microwave irradiation

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With piperidine; ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; xylene;

Reference yield:

: 1399843-33-4
{(2S,5S)-2-[2-(4-bromo-phenyl)-2-oxo-ethylcarbamoyl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

: 1399845-48-7
methyl (2S,5S)-2-(5-(4'-(2-((R)-morpholin-3-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / xylene / 4 h / 140 °C / Sealed tube

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 0.25 h / 135 °C / Sealed tube; Inert atmosphere; Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With ammonium acetate; sodium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; xylene;