4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

Base Information

Chemical Name:4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine
CAS No.:1380075-77-3
Molecular Formula:C₂₆H₂₈BrNO₂
Molecular Weight:466.418
Hs Code.:

Synonyms:4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

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Technology Process of 4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

There total 5 articles about 4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1380075-76-2
5-(4-benzyloxy-3-isopropylphenoxy)-6-bromo-8-nitro-1,2,3,4-tetrahydronaphthalene

: 1380075-77-3
4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.03.056

Reference yield:

: 1380075-75-1
2-bromo-4-nitro-5,6,7,8-tetrahydronaphthalen-1-ol

: 1380075-77-3
4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: bronze powder; triethylamine / dichloromethane / 120 h / 20 °C

2: platinum(IV) oxide; hydrogen / ethyl acetate / 2 h / 20 °C

With platinum(IV) oxide; bronze powder; hydrogen; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2012.03.056

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 1380075-77-3
4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 29 h / Reflux

2.1: iodine tris(trifluoroacetate); acetic anhydride; trifluoroacetic acid / 16 h / 4 °C

2.2: 0.5 h

3.1: bronze powder; triethylamine / dichloromethane / 120 h / 20 °C

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 2 h / 20 °C

With platinum(IV) oxide; bronze powder; iodine tris(trifluoroacetate); hydrogen; acetic anhydride; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2012.03.056