1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine

Base Information

• Chemical Name: 1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine
• CAS No.: 155106-81-3
• Molecular Formula: C₂₁H₂₇ClN₂O
• Molecular Weight: 358.911
• Mol file: 155106-81-3.mol

Synonyms:1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine

Chemical Property of 1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine

There total 1 articles about 1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(chloromethyl)benzyl chloride (626-16-4) + 2-(1-methylethoxy)phenyl-1-piperazine (54013-91-1) → 1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine (155106-81-3)

Guidance literature:

DOI:10.1021/jm00034a003

Reference yield:

piperidine (110-89-4) + 1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine (155106-81-3) → 1-<<3-<<1-<2-(1-methylethoxy)phenyl>-4-piperazinyl>methyl>phenyl>methyl>piperidine

Guidance literature:

With sodium carbonate; In water; ethyl acetate; at 50 ℃; for 3h;

DOI:10.1021/jm00021a010

Reference yield:

1-(3-Chloromethyl-benzyl)-4-(2-isopropoxy-phenyl)-piperazine (155106-81-3) → 1-<<3-(hydroxymethyl)phenyl>methyl>-4-<2-(1-methylethoxy)phenyl>piperazine

Guidance literature:

Multi-step reaction with 2 steps

1: 18-crown-6 / acetonitrile / 4 h / Heating

2: KOH / methanol / a) overnight, b) reflux, 20 min

With potassium hydroxide; 18-crown-6 ether; In methanol; acetonitrile;

DOI:10.1021/jm00021a010

upstream raw materials:

3-(chloromethyl)benzyl chloride

2-(1-methylethoxy)phenyl-1-piperazine

Downstream raw materials:

1-<<3-(acetoxymethyl)phenyl>methyl>-4-<2-(1-methylethoxy)phenyl>piperazine