1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Base Information

Chemical Name:1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine
CAS No.:1356963-21-7
Molecular Formula:C₁₇H₂₅FN₄O₃
Molecular Weight:352.409
Hs Code.:

Synonyms:1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

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Chemical Property of 1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

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Technology Process of 1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

There total 3 articles about 1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2-difluoro-4-methoxy-5-nitro-benzene: 66684-64-8
1,2-difluoro-4-methoxy-5-nitro-benzene

: 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine

: 1356963-21-7
1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Guidance literature:: 1,2-difluoro-4-methoxy-5-nitro-benzene; 1-methyl-4-(piperidin-4-yl)piperazine; In dimethyl sulfoxide; at 90 ℃; for 1h;

With sodium hydrogencarbonate; at 20 ℃;

Reference yield:

: 55346-97-9
4,5-difluoro-2-nitro-phenol

: 1356963-21-7
1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: dimethyl sulfoxide / 1 h / 90 °C

2.2: 20 °C

With potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 2713-33-9
3,4-difluorophenol

: 1356963-21-7
1-(1-(2-Fluoro-5-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid; tetrabutylammomium bromide / 1,1-dichloroethane / 14.75 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: dimethyl sulfoxide / 1 h / 90 °C

3.2: 20 °C

With tetrabutylammomium bromide; nitric acid; potassium carbonate; In 1,1-dichloroethane; dimethyl sulfoxide; N,N-dimethyl-formamide;