N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Base Information

Chemical Name:N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
CAS No.:1402598-45-1
Molecular Formula:C₂₄H₂₁NO₅S₂
Molecular Weight:467.566
Hs Code.:

Synonyms:N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Chemical Property of N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Technology Process of N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

There total 6 articles about N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402599-43-2
N-((5-(benzyloxy)-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

: 1402598-45-1
N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane; for 15h; under 760.051 Torr;

Reference yield:

: 19301-35-0
benzo[b]thiophen-5-ol

: 1402598-45-1
N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 0.08 h

3.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 15 h / 760.05 Torr

With n-butyllithium; hydrogen; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 20532-30-3
5-methoxybenzothiophene

: 1402598-45-1
N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine hydrochloride / 3.5 h / 190 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 0.08 h

4.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 15 h / 760.05 Torr

With n-butyllithium; hydrogen; pyridine hydrochloride; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;