20532-30-3

Basic information

• Product Name: 5-methoxy-1-benzothiophene
• Synonyms: 5-methoxy-1-benzothiophene;5-METHOXYBENZO[B]THIOPHENE;Benzo[b]thiophene, 5-Methoxy-
• CAS NO: 20532-30-3
• Molecular Formula: C₉H₈OS
• Molecular Weight: 164.23
• Mol File: 20532-30-3.mol
• Article Data: 19

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 268.874 °C at 760 mmHg
• Flash Point: 116.411 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-methoxy-1-benzothiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-1-benzothiophene(20532-30-3)
• EPA Substance Registry System: 5-methoxy-1-benzothiophene(20532-30-3)

Safety Data

• Hazardous Substances Data: 20532-30-3(Hazardous Substances Data)

Usage

General Description

5-Methoxy-1-benzothiophene is a chemical compound with the molecular formula C9H8OS. It is a benzothiophene derivative which consists of a benzene ring fused to a thiophene ring with a methoxy group attached to the 5-position of the benzene ring. 5-Methoxy-1-benzothiophene is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in organic synthesis as a building block for the preparation of various functional materials and organic compounds. 5-Methoxy-1-benzothiophene is an important chemical in the field of organic chemistry and has various applications in the production of fine chemicals.

InChI:InChI=1/C9H8OS/c1-10-8-2-3-9-7(6-8)4-5-11-9/h2-6H,1H3

Upstream product

• 19301-35-0 benzo[b]thiophen-5-ol 
• 77-78-1 dimethyl sulfate 
• 858816-12-3 (4-methoxy-phenylsulfanyl)-acetaldehyde dimethylacetal 
• 67-56-1 methanol 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 91906-21-7 4-methoxythiophenoxylacetaldehyde dimethyl acetal 
• 72002-19-8 2,3-dihydro-5-methoxybenzo[b]thiophen-3-one 
• 696-63-9 4-Methoxybenzenethiol 
• 38050-71-4 9-methoxy-9-BBN 
• 20532-33-6 5-chlorobenzothiophene 
• 23046-02-8 5-(methoxy)-1-benzothiophene-2-carboxylic acid 
• 124-41-4 sodium methylate 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 82301-36-8 (2-formyl-4-nitro-phenylsulfanyl)-acetic acid 

Downstream Products

• 193965-31-0 5-methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene 
• 19301-35-0 benzo[b]thiophen-5-ol 
• 53299-66-4 5-methoxy-2-methylbenzo[b]thiophene 
• 193965-32-1 4-Fluorophenyl 5-Methoxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl Ketone 
• 35134-07-7 3-methoxy-2-thiophenecarboxaldehyde 
• 98316-32-6 4-methoxy-thiophene-2-carboxaldehyde 
• 19492-99-0 methyl 5-methoxylbenzo[b]thiophene-2-carboxylate 
• 270929-89-0 5-methoxy-3-phenyl-1-benzothiophene 
• 1402598-40-6 N-((5-methoxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1402598-45-1 N-((5-hydroxy-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1402599-43-2 N-((5-(benzyloxy)-1-benzothiophen-2-yl)(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1373162-73-2 (R)-N-(3-(benzo[b]thiophen-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide 
• 193965-30-9 5-methoxybenzo[b]thiophen-2-yl-2-boronic acid 
• 641633-30-9 C₆₉H₆₈F₆N₂O₄S₂ 

Relevant articles and documents

5-Substituted Benzothiophenes: Synthesis, Mechanism, and Kinetic Studies

The kinetics of the reaction of 4-methoxythiophenoxyacetaldehyde diethyl acetal, 4-nitrothiophenoxyacetaldehyde diethyl acetal, and 3-methoxythiophenoxyacetaldehyde diethyl acetal in polyphosphoric acid has been explained. The kinetic behavior has been ex

Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.

New heteroaryl carbamates: Synthesis and biological screening in vitro and in mammalian cells of wild-type and mutant HIV-protease inhibitors

New heteroaryl HIV-protease inhibitors bearing a carbamoyl spacer were synthesized in few steps and high yield, from commercially available homochiral epoxides. Different substitution patterns were introduced onto a given isopropanoyl-sulfonamide core that can have either H or benzyl group. The in vitro inhibition activity against recombinant protease showed a general beneficial effect of both carbamoyl moiety and the benzyl group, ranging the IC50 values between 11 and 0.6 nM. In particular, benzofuryl and indolyl derivatives showed IC50 values among the best for such structurally simple inhibitors. Docking analysis allowed to identify the favorable situation of such derivatives in terms of number of interactions in the active site, supporting the experimental results. The inhibition activity was also confirmed in HEK293 mammalian cells and was maintained against protease mutants. Furthermore, the metabolic stability was comparable with that of the commercially available inhibitors.