methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate

Base Information

• Chemical Name: methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate
• CAS No.: 1273585-65-1
• Molecular Formula: C₁₄H₁₈FNO₄
• Molecular Weight: 283.3
• Mol file: 1273585-65-1.mol

Synonyms:methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate

Chemical Property of methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate

There total 7 articles about methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon dioxide (124-38-9,18923-20-1) + [Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester → methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate (1273585-65-1)

Guidance literature:

carbon dioxide; [Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester; With toluene-4-sulfonic acid; cesium fluoride; dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane; In N,N-dimethyl-formamide; at 20 ℃; for 3h; under 3750.38 Torr;

diazomethane; In diethyl ether;

DOI:10.1021/ol302952r

Reference yield: 79.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon dioxide (124-38-9,18923-20-1) + [Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester → methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate (1273585-65-1) + (4-fluorobenzyl)carbamic acid tert-butyl ester (153903-23-2)

Guidance literature:

carbon dioxide; [Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester; With trimethylsilyltributyltin; cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 3h; under 7500.75 Torr;

diazomethane; In diethyl ether;

DOI:10.1021/ol302952r

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + α-amino-4-fluorobenzeneacetic acid methyl ester (42718-13-8,170902-76-8) → methyl 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetate (1273585-65-1)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/j.ejmech.2016.01.015

upstream raw materials:

diazomethane

carbon dioxide

N-(tert-butoxycarbonyl)-α-(tributylstannyl)-4-fluorobenzylamine

diazomethyl-trimethyl-silane