5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Base Information

Chemical Name:5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione
CAS No.:475089-51-1
Molecular Formula:C₂₂H₂₄O₇
Molecular Weight:400.428
Hs Code.:

Synonyms:5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Suppliers and Price of 5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

There total 11 articles about 5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2033-24-1
cycl-isopropylidene malonate

: 475089-50-0
5-benzyloxy-4,4-dimethyl-3-oxohept-6-ynoic acid

: 475089-51-1
5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jo0204707

Reference yield:

: 89897-24-5
2,2-dimethylpent-4-yne-1,3-diol

: 475089-51-1
5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: 81 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 16 h / 20 °C

2.1: NaH / tetrahydrofuran / 16 h / 20 °C

3.1: 901 mg / tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 20 °C

4.1: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -78 - 20 °C

5.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.67 h / -78 °C

5.2: 98 percent / tetrahydrofuran; hexane / -78 - 20 °C

6.1: 60 percent / pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 16 h / 20 °C

7.1: 76 percent / trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 0 °C

8.1: 86 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h / 20 °C

With dmap; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; diisopropylamine; dicyclohexyl-carbodiimide; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0204707

Reference yield:

: 475089-47-5
3-benzyloxy-2,2-dimethylpent-4-ynal

: 475089-51-1
5-(1,3-dioxo-4,4-dimethyl-5-benzyloxyhept-6-ynyl)-2,2-dimethyl[1,3]dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: 98 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 60 percent / pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 16 h / 20 °C

3.1: 76 percent / trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 0 °C

4.1: 86 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h / 20 °C

With dmap; n-butyllithium; sodium acetate; diisopropylamine; dicyclohexyl-carbodiimide; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0204707