Technology Process of 5-benzyloxy-4,4-dimethyl-3-oxohept-6-ynoic acid
There total 10 articles about 5-benzyloxy-4,4-dimethyl-3-oxohept-6-ynoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 2.5h;
DOI:10.1021/jo0204707
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 81 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 16 h / 20 °C
2.1: NaH / tetrahydrofuran / 16 h / 20 °C
3.1: 901 mg / tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 20 °C
4.1: 92 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / 2 h / -78 - 20 °C
5.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.67 h / -78 °C
5.2: 98 percent / tetrahydrofuran; hexane / -78 - 20 °C
6.1: 60 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 16 h / 20 °C
7.1: 76 percent / trifluoroacetic acid / CH2Cl2 / 2.5 h / 0 °C
With
dmap; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0204707
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 0.67 h / -78 °C
1.2: 98 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 60 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 16 h / 20 °C
3.1: 76 percent / trifluoroacetic acid / CH2Cl2 / 2.5 h / 0 °C
With
n-butyllithium; sodium acetate; diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0204707
