2-(4-Bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Base Information

Chemical Name:2-(4-Bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
CAS No.:188744-97-0
Molecular Formula:C₁₁H₁₄BrNO₃
Molecular Weight:288.141
Hs Code.:
DSSTox Substance ID:DTXSID80699471
Mol file:188744-97-0.mol

Synonyms:188744-97-0;DTXSID80699471;2-(4-bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;3,4-Pyrrolidinediol, 2-(4-bromophenyl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-

Suppliers and Price of 2-(4-Bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(4-Bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

Chemical Property:

PSA：72.72000
LogP:0.50490
XLogP3:0.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:287.01571
Heavy Atom Count:16
Complexity:233

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2C(C(C(N2)CO)O)O)Br

Technology Process of 2-(4-Bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

There total 4 articles about 2-(4-Bromophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153172-31-7
(3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole

: 188744-97-0
1-(S)-(4-bromophenyl)-1,4-dideoxy-1,4-imino-D-ribitol

Guidance literature:: Multi-step reaction with 4 steps

1: NCS / pentane / 0.5 h / Ambient temperature

2: 1.) BuLi, 2,2,6,6-tetramethylpiperidine / 1.) THF, 0 deg C, 2.) THF, -78 deg C

3: 55 percent / tetrahydrofuran / 1 h / -78 °C

4: 1.) 50percent trifluoroacetic acid, 2.) Amberlyst A 26 (OH^- form) / 1.) H₂O, room temperature, 3 h, 2.) H₂O

With 2,2,6,6-tetramethyl-piperidine; N-chloro-succinimide; n-butyllithium; Amberlyst A 26 (OH^- form); trifluoroacetic acid; In tetrahydrofuran; pentane;
DOI:10.1016/S0040-4020(96)01172-6

Reference yield:

: 153172-32-8
(3aR,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-chloro-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

: 188744-97-0
1-(S)-(4-bromophenyl)-1,4-dideoxy-1,4-imino-D-ribitol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BuLi, 2,2,6,6-tetramethylpiperidine / 1.) THF, 0 deg C, 2.) THF, -78 deg C

2: 55 percent / tetrahydrofuran / 1 h / -78 °C

3: 1.) 50percent trifluoroacetic acid, 2.) Amberlyst A 26 (OH^- form) / 1.) H₂O, room temperature, 3 h, 2.) H₂O

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; Amberlyst A 26 (OH^- form); trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/S0040-4020(96)01172-6

Reference yield:

: 153172-33-9
(3aR,4R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole

: 188744-97-0
1-(S)-(4-bromophenyl)-1,4-dideoxy-1,4-imino-D-ribitol

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / tetrahydrofuran / 1 h / -78 °C

2: 1.) 50percent trifluoroacetic acid, 2.) Amberlyst A 26 (OH^- form) / 1.) H₂O, room temperature, 3 h, 2.) H₂O

With Amberlyst A 26 (OH^- form); trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/S0040-4020(96)01172-6