N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

Base Information

Chemical Name:N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester
CAS No.:128217-79-8
Molecular Formula:C₃₀H₃₂N₂O₉
Molecular Weight:564.592
Hs Code.:

Synonyms:N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

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Chemical Property of N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

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Technology Process of N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

There total 7 articles about N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 128217-68-5
N-[2-(3,4-Bis-benzyloxy-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

: 128217-79-8
N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

Guidance literature:: With nitric acid; In acetic acid; at 0 ℃; for 2h;
DOI:10.1021/jo00301a008

Reference yield:

: 63-84-3,90638-38-3
dopa

: 128217-79-8
N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 48 h / Ambient temperature

2: NaHCO₃ / H₂O; tetrahydrofuran / overnight

3: K₂CO₃, NaI / ethanol / 4 h / Heating

4: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

5: NaHCO₃ / H₂O; ethyl acetate / Ambient temperature; overnight

6: 90 percent / nitric acid (d = 1.4) / acetic acid / 2 h / 0 °C

With thionyl chloride; nitric acid; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; ethyl acetate;
DOI:10.1021/jo00301a008

Reference yield:

: 23234-41-5
L-Dopa ethyl ester hydrochloride

: 128217-79-8
N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaHCO₃ / H₂O; tetrahydrofuran / overnight

2: K₂CO₃, NaI / ethanol / 4 h / Heating

3: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

4: NaHCO₃ / H₂O; ethyl acetate / Ambient temperature; overnight

5: 90 percent / nitric acid (d = 1.4) / acetic acid / 2 h / 0 °C

With nitric acid; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; ethyl acetate;
DOI:10.1021/jo00301a008