N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

Base Information

Chemical Name:N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester
CAS No.:128217-86-7
Molecular Formula:C₂₈H₂₈N₂O₆
Molecular Weight:488.54
Hs Code.:

Synonyms:N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

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Chemical Property of N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

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Technology Process of N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

There total 7 articles about N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 128217-79-8
N-[2-(4,5-Bis-benzyloxy-2-nitro-phenyl)-1-ethoxycarbonyl-ethyl]-succinamic acid methyl ester

: 128217-86-7
N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

Guidance literature:: With iron; acetic acid; at 90 - 100 ℃; for 3h;
DOI:10.1021/jo00301a008

Reference yield:

: 23234-41-5
L-Dopa ethyl ester hydrochloride

: 128217-86-7
N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaHCO₃ / H₂O; tetrahydrofuran / overnight

2: K₂CO₃, NaI / ethanol / 4 h / Heating

3: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

4: NaHCO₃ / H₂O; ethyl acetate / Ambient temperature; overnight

5: 90 percent / nitric acid (d = 1.4) / acetic acid / 2 h / 0 °C

6: 90 percent / iron powder, glacial acetic acid / 3 h / 90 - 100 °C

With nitric acid; iron; sodium hydrogencarbonate; potassium carbonate; acetic acid; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; ethyl acetate;
DOI:10.1021/jo00301a008

Reference yield:

: 52787-46-9
succinic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester

: 128217-86-7
N-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / H₂O; ethyl acetate / Ambient temperature; overnight

2: 90 percent / nitric acid (d = 1.4) / acetic acid / 2 h / 0 °C

3: 90 percent / iron powder, glacial acetic acid / 3 h / 90 - 100 °C

With nitric acid; iron; sodium hydrogencarbonate; acetic acid; In water; acetic acid; ethyl acetate;
DOI:10.1021/jo00301a008