cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

Base Information

Chemical Name:cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate
CAS No.:1063410-22-9
Molecular Formula:C₂₅H₃₄N₄O₂S
Molecular Weight:454.637
Hs Code.:

Synonyms:cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

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Chemical Property of cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

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Technology Process of cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

There total 9 articles about cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1063410-18-3
C₂₀H₃₁N₃O₂

: methyl thiophene-2-carbimidothioate hydroiodide

cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate: 1063410-22-9
cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

Guidance literature:: In ethanol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.07.006

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate: 1063410-22-9
cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: hydrogenchloride / water; acetone / 16 h / 20 °C / Inert atmosphere

4: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

5: triethylamine / 1,4-dioxane / 20 °C / Inert atmosphere

6: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; lithium hexamethyldisilazane / tetrahydrofuran; hexane / 20 - 100 °C / Sealed tube; Inert atmosphere

7: tetrabutyl ammonium fluoride / tetrahydrofuran; hexane / 20 °C / Sealed tube; Inert atmosphere

8: ethanol / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; sodium cyanoborohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 6: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2012.07.006

Reference yield:

: 1063410-05-8
1-(1,4-dioxaspiro[4.5]decan-8-yl)indoline

cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate: 1063410-22-9
cis-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: hydrogenchloride / water; acetone / 16 h / 20 °C / Inert atmosphere

3: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

4: triethylamine / 1,4-dioxane / 20 °C / Inert atmosphere

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; lithium hexamethyldisilazane / tetrahydrofuran; hexane / 20 - 100 °C / Sealed tube; Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran; hexane / 20 °C / Sealed tube; Inert atmosphere

7: ethanol / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; sodium cyanoborohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; water; N,N-dimethyl-formamide; acetone; 5: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2012.07.006