N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Base Information

Chemical Name:N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester
CAS No.:301843-67-4
Molecular Formula:C₄₄H₅₅N₃O₁₂Si
Molecular Weight:846.019
Hs Code.:

N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Synonyms:N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Suppliers and Price of N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

There total 11 articles about N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 221325-35-5
chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane

: 301843-70-9
N-(9-fluorenylmethoxycarbonyl)-O-(2-acetamido-2-deoxy-3,4-O-isopropylidene-α-D-galactopyranosyl)-L-threonine allyl ester

: 301843-67-4
N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at -20 ℃; for 0.75h;
DOI:10.1016/S0040-4020(00)00588-3

Reference yield: 91.0%

: 77-76-9
2,2-dimethoxy-propane

: 301843-66-3
N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

: 301843-67-4
N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Guidance literature:: With camphor-10-sulfonic acid; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1016/S0040-4020(00)00588-3

Reference yield:

: (2S,3R)-3-((4aR,6S,7R,8R,8aR)-7-Azido-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid allyl ester

: 301843-67-4
N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester

Guidance literature:: Multi-step reaction with 7 steps

2: 97 percent

3: 365 mg / camphorsulfonic acid / acetonitrile / 5 h / 20 °C

4: Zn; AcOH / CH₂Cl₂ / 0.33 h / 20 °C

5: 336 mg / methanol / 0.5 h / 20 °C

6: 92 percent / AcOH; Bu₄NF / tetrahydrofuran / 4 h / 0 - 4 °C

7: 97 percent / NaI / dimethylformamide / 0.75 h / -20 °C

With camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; acetic acid; sodium iodide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: debenzylidenation / 2: silylation / 3: Cyclization / 4: Reduction / 5: Acetylation / 6: desilylation / 7: silylation;
DOI:10.1016/S0040-4020(00)00588-3