1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

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Chemical Name:1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide
CAS No.:1352753-82-2
Molecular Formula:C₃₁H₃₆N₄O₃
Molecular Weight:512.652
Hs Code.:

1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Synonyms:1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

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Chemical Property of 1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

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Technology Process of 1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

There total 4 articles about 1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1151795-87-7
(S)-4-(2-hydroxy-2-methylpropyl)-4-phenyl-1-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}tetrahydro-pyrimidin-2(1H)-one

: 1352753-97-9
1-(5-bromo-pyridin-2-yl)-cyclopropanecarboxylic acid amide

: 1352753-82-2
1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 766-11-0
5-bromo-2-fluoropyridine

: 1352753-82-2
1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / toluene / 0.08 h / Cooling with ice

2.1: sulfuric acid / 20 °C

2.2: Cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 2 h / 100 °C / Inert atmosphere

With sulfuric acid; potassium hexamethylsilazane; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene;

Reference yield:

: 312325-72-7
2-(5-bromopyridin-2-yl)acetonitrile

: 1352753-82-2
1-[5-(4-{(S)-1-[(S)-4-(2-hydroxy-2-methyl-propyl)-2-oxo-4-phenyl-tetrahydro-pyrimidin-1-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / acetonitrile; water / 4 h / 20 °C

2.1: sulfuric acid / 20 °C

2.2: Cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 2 h / 100 °C / Inert atmosphere

With sulfuric acid; benzyltri(n-butyl)ammonium chloride; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; acetonitrile;