4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Base Information

Chemical Name:4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole
CAS No.:757188-90-2
Molecular Formula:C₂₀H₂₀ClN₃O
Molecular Weight:353.851
Hs Code.:

Synonyms:4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

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Chemical Property of 4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

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Technology Process of 4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

There total 4 articles about 4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 74-88-4
methyl iodide

: 757188-84-4
4'-(4-chlorophenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

: 757188-90-2
4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;
DOI:10.1016/j.bmc.2006.09.022

Reference yield:

: 757188-84-4
4'-(4-chlorophenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

: 757188-90-2
4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 25 ℃;
DOI:10.1016/j.tetlet.2004.06.047

Reference yield:

: 683212-52-4
methyl 3-amino-4-(p-chlorophenyl)-1H-pyrrole-2-carboxylate

: 757188-90-2
4'-(4-chlorophenyl)-1'-methyl-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / 4-chloropyridine hydrochloride / dioxane / 100 °C

2: 48 percent / Heating

3: 85 percent / sodium hydride / dimethylformamide / 1 h / 25 °C

With 4-chlorpyridine hydrochloride; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Clauson-Kaas reaction;
DOI:10.1016/j.bmc.2006.09.022