N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea

Base Information

• Chemical Name: N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea
• CAS No.: 1305317-22-9
• Molecular Formula: C₂₈H₂₃N₅O₃
• Molecular Weight: 477.522
• Mol file: 1305317-22-9.mol

Synonyms:N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea

Chemical Property of N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea

There total 10 articles about N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

8-amino-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine (1305317-11-6) + phenyl isocyanate (103-71-9) → N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea (1305317-22-9)

Guidance literature:

8-amino-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

phenyl isocyanate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 6h;

DOI:10.1055/s-0030-1259429

Reference yield:

4-aminopyridine (504-24-5) → N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea (1305317-22-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sulfuric acid; nitric acid / 5.5 h / 10 - 20 °C

2.1: sulfuric acid / 20 - 90 °C

3.1: potassium acetate; acetic acid / 1 h / 20 °C

3.2: 20 °C

4.1: water; tin(ll) chloride / ethanol / 2 h / Reflux

5.1: 1,4-dioxane / Reflux

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 75 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

8.2: 6 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sulfuric acid; hydroxylamine hydrochloride; water; nitric acid; potassium acetate; sodium acetate; sodium hydride; acetic acid; tin(ll) chloride; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene; mineral oil; 6.1: Buchwald reaction;

DOI:10.1055/s-0030-1259429

Reference yield:

3,4,5-triaminopyridine (618439-82-0) → N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea (1305317-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 6 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1055/s-0030-1259429

upstream raw materials:

4-aminopyridine

3,4,5-triaminopyridine

3,4-diamino-5-bromopyridine

4-(nitroamino)pyridine