3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

Base Information

Chemical Name:3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine
CAS No.:1617498-90-4
Molecular Formula:C₂₂H₂₈N₆O
Molecular Weight:392.504
Hs Code.:

Synonyms:3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

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Chemical Property of 3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

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Technology Process of 3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

There total 5 articles about 3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1617499-16-7
5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine

: 364794-81-0
4-{2-[4-(4,4,5,5-tetramethyl[1,3,2] dioxaborolan-2-yl)phenyl]ethyl}morpholine

: 1617498-90-4
3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1210838-82-6
5-bromo-3-ethynyl-pyridin-2-ylamine

: 1617498-90-4
3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C

1.2: 16 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; caesium carbonate; In 1,4-dioxane; water; tert-butyl alcohol;

Reference yield:

: 1798-06-7
(4-iodophenyl)acetic acid

: 1617498-90-4
3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C

2.2: 16 h / 0 - 20 °C

2.3: 0 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trifluoride diethyl etherate; potassium acetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;