364794-81-0

Basic information

• Product Name: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine
• Synonyms: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine;4-(2-Morpholinoethyl)phenylboronic acid, pinacol ester;4-[2-phenyl-1-(tetraMethyl-1,3,2-dioxaborolan-2-yl)ethyl]Morpholine;4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)morpholin
• CAS NO: 364794-81-0
• Molecular Formula: C₁₈H₂₈BNO₃
• Molecular Weight: 317.23082
• Mol File: 364794-81-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine(364794-81-0)
• EPA Substance Registry System: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine(364794-81-0)

Safety Data

• Hazardous Substances Data: 364794-81-0(Hazardous Substances Data)

Usage

General Description

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine, also known as TMDP, is a chemical compound used as a ligand in various organic synthesis reactions. It is commonly employed in the formation of carbon-carbon and carbon-nitrogen bonds in organic molecules. TMDP is a versatile and effective reagent due to its unique boron-based structure, which allows it to participate in a variety of chemical reactions. It is widely utilized in pharmaceutical and agrochemical industries for the production of complex organic compounds. Additionally, TMDP has been studied for its potential applications in materials science and catalysis due to its ability to facilitate selective and efficient chemical transformations. Overall, 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine is an important and valuable reagent in synthetic chemistry.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 736991-39-2 4-[2-(4-bromophenyl)ethyl]morpholine 
• 1746-28-7 1-bromo-4-(2-bromoethyl)benzene 
• 364793-89-5 2-(4-iodophenyl)-1-morpholin-4-ylethanone 
• 1798-06-7 (4-iodophenyl)acetic acid 
• 100839-46-1 4-[2-(4-iodophenyl)ethyl]morpholine 

Downstream Products

• 910461-31-3 (E)-3-{1-[4'-(2-morpholin-4-yl-ethyl)-biphenyl-3-sulfonyl]-1H-pyrrol-3-yl}-N-(tetrahydro-pyran-2-yloxy)-acrylamide 
• 1617498-90-4 3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine 

Relevant articles and documents

Photo-induced thiolate catalytic activation of inert Caryl-hetero bonds for radical borylation

Substantial effort is currently being devoted to obtaining photoredox catalysts with high redox power. Yet, it remains challenging to apply the currently established methods to the activation of bonds with high bond dissociation energy and to substrates with high reduction potentials. Herein, we introduce a novel photocatalytic strategy for the activation of inert substituted arenes for aryl borylation by using thiolate as a catalyst. This catalytic system exhibits strong reducing ability and engages non-activated Caryl–F, Caryl–X, Caryl–O, Caryl–N, and Caryl–S bonds in productive radical borylation reactions, thus expanding the available aryl radical precursor scope. Despite its high reducing power, the method has a broad substrate scope and good functional-group tolerance. Spectroscopic investigations and control experiments suggest the formation of a charge-transfer complex as the key step to activate the substrates.

AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS

The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.