Technology Process of 1,3-Dioxol-2-one,4-(hydroxymethyl)-5-(1-methylethyl)-(9CI)
There total 6 articles about 1,3-Dioxol-2-one,4-(hydroxymethyl)-5-(1-methylethyl)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-isopropyl-2-oxo-[1,3]dioxole-4-carboxylic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
With
tetrabutylammonium borohydride;
In
dichloromethane;
at -78 ℃;
DOI:10.1016/S0040-4039(01)02386-3
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: p-toluenesulfonylazide; Et3N / acetonitrile / 0 - 20 °C
2.1: Rh2(OAc)4 / tetrahydrofuran; H2O / Heating
3.1: i-Pr2NEt / tetrahydrofuran / 0 °C
4.1: hydrogen / Pd(OH)2 on carbon / ethanol / 760 Torr
5.1: oxalyl chloride; DMF / CH2Cl2 / 0 - 20 °C
5.2: Bu4NBH4 / CH2Cl2 / -78 °C
With
4-toluenesulfonyl azide; oxalyl dichloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
dirhodium tetraacetate; palladium hydroxide - carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(01)02386-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: DMAP / toluene / Heating
2.1: p-toluenesulfonylazide; Et3N / acetonitrile / 0 - 20 °C
3.1: Rh2(OAc)4 / tetrahydrofuran; H2O / Heating
4.1: i-Pr2NEt / tetrahydrofuran / 0 °C
5.1: hydrogen / Pd(OH)2 on carbon / ethanol / 760 Torr
6.1: oxalyl chloride; DMF / CH2Cl2 / 0 - 20 °C
6.2: Bu4NBH4 / CH2Cl2 / -78 °C
With
dmap; 4-toluenesulfonyl azide; oxalyl dichloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
dirhodium tetraacetate; palladium hydroxide - carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(01)02386-3