tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine

Base Information

• Chemical Name: tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine
• CAS No.: 241813-24-1
• Molecular Formula: C₁₉H₂₃N
• Molecular Weight: 265.398
• Mol file: 241813-24-1.mol

Synonyms:tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine

Chemical Property of tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine

There total 2 articles about tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylamine (75-64-9) + 2-(1-cyclohexenylethynyl)benzaldehyde (391611-24-8) → tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine (241813-24-1)

Guidance literature:

DOI:10.1021/jo026016k

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine (241813-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 70 °C / Inert atmosphere

2: dichloromethane / 20 °C / Molecular sieve

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane;

DOI:10.1002/anie.201606381

Reference yield: 56.0%

tert-Butyl-[1-(2-cyclohex-1-enylethynyl-phenyl)-meth-(E)-ylidene]-amine (241813-24-1) → 3-(cyclohex-1-en-1-yl)-4-fluoroisoquinoline (1404078-14-3)

Guidance literature:

With lithium carbonate; silver nitrate; N-fluorobis(benzenesulfon)imide; In N,N-dimethyl acetamide; at 30 ℃; regioselective reaction; Sealed tube;

DOI:10.1021/ol3026507

upstream raw materials:

tert-butylamine

2-(1-cyclohexenylethynyl)benzaldehyde

ortho-bromobenzaldehyde

Downstream raw materials:

3-(cyclohex-1-en-1-yl)-4-fluoroisoquinoline