Carbamic acid, [(1R)-1-(hydroxymethyl)-3-butenyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1R)-1-(hydroxymethyl)-3-butenyl]-, 1,1-dimethylethyl ester
• CAS No.: 188359-85-5
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.266
• DSSTox Substance ID: DTXSID20455396
• Mol file: 188359-85-5.mol

Synonyms:Carbamic acid, [(1R)-1-(hydroxymethyl)-3-butenyl]-, 1,1-dimethylethyl ester

Chemical Property of Carbamic acid, [(1R)-1-(hydroxymethyl)-3-butenyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 62.05000
• LogP: 1.65250
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 201.13649347
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

97% ^*data from raw suppliers

(1R)-(1-Hydroxymethyl-but-3-enyl)-carbamicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC=C)CO
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@H](CC=C)CO

Technology Process of Carbamic acid, [(1R)-1-(hydroxymethyl)-3-butenyl]-, 1,1-dimethylethyl ester

There total 8 articles about Carbamic acid, [(1R)-1-(hydroxymethyl)-3-butenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C13H23NO3 → (R)-tert-butyl (1-hydroxypent-4-en-2-yl)carbamate (188359-85-5,116613-81-1)

Guidance literature:

With copper(II) choride dihydrate; In acetonitrile; at 0 ℃; for 0.5h; Concentration; Temperature;

Reference yield: 79.0%

(R)-2-(tert-butoxycarbonyl)amino-4-pentenoic acid methyl ester (150652-96-3) → (R)-tert-butyl (1-hydroxypent-4-en-2-yl)carbamate (188359-85-5,116613-81-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

DOI:10.1039/c0ob00871k

Reference yield: 71.0%

C24H39N3O10 → (R)-tert-butyl (1-hydroxypent-4-en-2-yl)carbamate (188359-85-5,116613-81-1)

Guidance literature:

With methanol; sodium tetrahydroborate; In ethanol; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(96)01077-0

upstream raw materials:

di-tert-butyl dicarbonate

(4R, 5S)-4-allyl-5-(1,2-bis(isopropoxycarbonyl)hydrazino)-2-oxazolidinone

(R)-methyl 2-((diphenylmethylene)amino)pent-4-enoate

(R)-2-(tert-butoxycarbonyl)amino-4-pentenoic acid methyl ester

Downstream raw materials:

(R)-methyl 2-(((2-((tert-butoxycarbonyl)amino)pent-4-en-1-yl)oxy)methyl)benzoate

(R)-1-((2-(bromomethyl)benzyl)oxy)pent-4-en-2-amine

(R)-tert-butyl (1-((2-(bromomethyl)benzyl)oxy)pent-4-en-2-yl)carbamate

(R)-tert-butyl (1-((2-(hydroxymethyl)benzyl)oxy)pent-4-en-2-yl)carbamate