14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

Base Information

Chemical Name:14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol
CAS No.:137725-23-6
Molecular Formula:C₂₈H₃₆O₄
Molecular Weight:436.591
Hs Code.:

Synonyms:14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

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Chemical Property of 14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

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Technology Process of 14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

There total 6 articles about 14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 137725-31-6
14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

: 137725-23-6
14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

Guidance literature:: With tetrahydrofuran; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1016/S0040-4020(01)89740-4

Reference yield: 55.0%

: 137725-22-5
(17)S-2',2'-dimethylspiro-<14-benzyloxymethyl-3-methoxyestra-1,3,5(10)-triene-17,4'<1,3>dioxolane>

: 137725-23-6
14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

Guidance literature:: With acetic acid; at 62 ℃; for 4h;
DOI:10.1016/S0040-4020(01)89740-4

Reference yield:

: 104512-90-5
14,17α-Diformyl-3-methoxy-14α-estra-1,3,5(10)-trien-17β-yl acetate

: 137725-23-6
14-benzyloxymethyl-17α-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 104 mg / lithium aluminium hydride / tetrahydrofuran / 3 h / 25 °C

2: 81 percent / imidazole / dimethylformamide / 0.5 h

3: 28 percent / 1.) NaH (50percent in oil) / 1.) dimethoxyethane, 0 deg C, 45 min., 2.) 20 deg C, 3 d

4: 89 percent / tetra-n-butylammonium fluoride/THF / tetrahydrofuran / 3 h / 25 °C

With tetrahydrofuran; 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89740-4