14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

Base Information

Chemical Name:14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol
CAS No.:137725-31-6
Molecular Formula:C₃₄H₅₀O₄Si
Molecular Weight:550.854
Hs Code.:

Synonyms:14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

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Chemical Property of 14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

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Technology Process of 14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

There total 3 articles about 14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 100-39-0
benzyl bromide

: 137725-29-2
17α-t-butyldimethylsilyloxymethyl-14-hydroxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

: 137725-32-7
17β-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-14-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene

: 137725-31-6
14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

: 137725-30-5
17β-benzyloxy-14-benzyloxymethyl-17α-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-triene

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) dimethoxyethane, 0 deg C, 45 min., 2.) 20 deg C, 3 d;
DOI:10.1016/S0040-4020(01)89740-4

Reference yield:

: 104512-90-5
14,17α-Diformyl-3-methoxy-14α-estra-1,3,5(10)-trien-17β-yl acetate

: 137725-31-6
14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 104 mg / lithium aluminium hydride / tetrahydrofuran / 3 h / 25 °C

2: 81 percent / imidazole / dimethylformamide / 0.5 h

3: 28 percent / 1.) NaH (50percent in oil) / 1.) dimethoxyethane, 0 deg C, 45 min., 2.) 20 deg C, 3 d

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89740-4

Reference yield:

: 137725-18-9
(8R,9S,13S,14R,17S)-14,17-Bis-hydroxymethyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

: 137725-31-6
14-benzyloxymethyl-17α-t-butyldimethylsilyloxymethyl-3-methoxyestra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / imidazole / dimethylformamide / 0.5 h

2: 28 percent / 1.) NaH (50percent in oil) / 1.) dimethoxyethane, 0 deg C, 45 min., 2.) 20 deg C, 3 d

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89740-4