N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

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Chemical Name:N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride
CAS No.:1431773-36-2
Molecular Formula:C₂₈H₃₃N₇O*ClH
Molecular Weight:520.077
Hs Code.:

Synonyms:N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

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Chemical Property of N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

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Technology Process of N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

There total 4 articles about N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 54035-94-8
N-(2-bromoethyl)pyrrolidine

: 1431773-31-7
4-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenol

: 1431773-36-2
N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

Guidance literature:: N-(2-bromoethyl)pyrrolidine; 4-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenol; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

With hydrogenchloride; In water; acetonitrile; pH=2;

Reference yield:

: 933190-51-3
8-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1431773-36-2
N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

2.1: XPhos; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 95 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

3.2: pH 2

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1415314-19-0
6-chloro-N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

: 1431773-36-2
N-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)imidazo[1,2-b]pyridazin-8-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: XPhos; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 95 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

2.2: pH 2

With sodium carbonate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;