N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

Base Information

Chemical Name:N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea
CAS No.:259225-21-3
Molecular Formula:C₃₃H₃₉BrN₄O₃
Molecular Weight:619.602
Hs Code.:

Synonyms:N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

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Chemical Property of N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

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Technology Process of N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

There total 11 articles about N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 259224-74-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-hydroxymethylphenyl)urea

: 259225-21-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 24544-04-5
2,6-diisopropylbenzenamine

: 259225-21-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / aq. HIO₃; I₂; acetic acid / H₂SO₄ / 5 h / 80 °C

2: 83 percent / Pd(OAc)2; DPP; Et₃N / dimethylformamide / 4 h / 80 °C

3: 98 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 60 °C

4: 83 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

5: 73 percent / DMAP / dimethylformamide / 20 °C

6: 89 percent / aq. HCl / ethanol / 3 h / 20 °C

7: 45 percent / PBr₃ / CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; dmap; palladium diacetate; lithium aluminium tetrahydride; parathion; iodine; phosphorus tribromide; iodic acid; acetic acid; triethylamine; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 664340-51-6
4-amino-3,5-diisopropylbenzenemethanol

: 259225-21-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2: 73 percent / DMAP / dimethylformamide / 20 °C

3: 89 percent / aq. HCl / ethanol / 3 h / 20 °C

4: 45 percent / PBr₃ / CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; dmap; phosphorus tribromide; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.056