Urea, N-[1-butyl-1,2-dihydro-4-(3-methoxyphenyl)-2-oxo-1,8-naphthyridin-3-yl]- N'-[4-(hydroxymethyl)-2,6-bis(1-methylethyl)phenyl]-

Base Information

Chemical Name:Urea, N-[1-butyl-1,2-dihydro-4-(3-methoxyphenyl)-2-oxo-1,8-naphthyridin-3-yl]- N'-[4-(hydroxymethyl)-2,6-bis(1-methylethyl)phenyl]-
CAS No.:259224-74-3
Molecular Formula:C33H40N4O4
Molecular Weight:556.705
Hs Code.:
Mol file:259224-74-3.mol

Synonyms:

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Chemical Property of Urea, N-[1-butyl-1,2-dihydro-4-(3-methoxyphenyl)-2-oxo-1,8-naphthyridin-3-yl]- N'-[4-(hydroxymethyl)-2,6-bis(1-methylethyl)phenyl]-

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Technology Process of Urea, N-[1-butyl-1,2-dihydro-4-(3-methoxyphenyl)-2-oxo-1,8-naphthyridin-3-yl]- N'-[4-(hydroxymethyl)-2,6-bis(1-methylethyl)phenyl]-

There total 10 articles about Urea, N-[1-butyl-1,2-dihydro-4-(3-methoxyphenyl)-2-oxo-1,8-naphthyridin-3-yl]- N'-[4-(hydroxymethyl)-2,6-bis(1-methylethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 259225-20-2
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-[2,6-diisopropyl-4-(tert-butyldimethylsilyloxymethyl)phenyl]urea

: 259224-74-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-hydroxymethylphenyl)urea

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 24544-04-5
2,6-diisopropylbenzenamine

: 259224-74-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-hydroxymethylphenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / aq. HIO₃; I₂; acetic acid / H₂SO₄ / 5 h / 80 °C

2: 83 percent / Pd(OAc)2; DPP; Et₃N / dimethylformamide / 4 h / 80 °C

3: 98 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 60 °C

4: 83 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

5: 73 percent / DMAP / dimethylformamide / 20 °C

6: 89 percent / aq. HCl / ethanol / 3 h / 20 °C

With hydrogenchloride; dmap; palladium diacetate; lithium aluminium tetrahydride; parathion; iodine; iodic acid; acetic acid; triethylamine; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 664340-51-6
4-amino-3,5-diisopropylbenzenemethanol

: 259224-74-3
N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-hydroxymethylphenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2: 73 percent / DMAP / dimethylformamide / 20 °C

3: 89 percent / aq. HCl / ethanol / 3 h / 20 °C

With hydrogenchloride; dmap; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.056