(1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

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Chemical Name:(1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene
CAS No.:187992-16-1
Molecular Formula:C₃₃H₃₄N₂O₄
Molecular Weight:522.644
Hs Code.:

Synonyms:(1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

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Chemical Property of (1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

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Technology Process of (1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

There total 11 articles about (1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-tert-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

: 584-08-7
potassium carbonate

: 105-36-2
ethyl bromoacetate

: 187992-16-1
(1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: (R)-1-Azido-5-methoxy-1,2,3,4-tetrahydro-naphthalene

: 187992-16-1
(1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / methanol

2: p-TsOH / toluene / Heating

3: NaBH₄ / methanol; tetrahydrofuran

4: BBr₃ / CH₂Cl₂

5: K₂CO₃ / dimethylformamide

6: SOCl₂ / CH₂Cl₂

7: K₂CO₃ / dimethylformamide

With sodium tetrahydroborate; thionyl chloride; hydrogen; boron tribromide; potassium carbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2005.04.042

Reference yield:

: 182497-75-2
(+)-(S)-5-Methoxy-1-tetralol

: 187992-16-1
(1R)-1-[(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-1-yl]-5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 8 steps

1: diphenyl phosphorazidate; DBU / toluene

2: H₂ / Pd/C / methanol

3: p-TsOH / toluene / Heating

4: NaBH₄ / methanol; tetrahydrofuran

5: BBr₃ / CH₂Cl₂

6: K₂CO₃ / dimethylformamide

7: SOCl₂ / CH₂Cl₂

8: K₂CO₃ / dimethylformamide

With sodium tetrahydroborate; thionyl chloride; diphenyl phosphoryl azide; hydrogen; boron tribromide; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2005.04.042