Technology Process of N-{4-[4-amino-6,7-dimethyl-2-({[(1-methylethylidene)amino]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]butyl}-N-cyclohexylurea
There total 7 articles about N-{4-[4-amino-6,7-dimethyl-2-({[(1-methylethylidene)amino]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]butyl}-N-cyclohexylurea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C41H50N7O2P;
With
water; acetic acid;
In
methanol;
at 50 - 55 ℃;
for 504h;
With
sodium carbonate;
In
chloroform; water;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: triethylamine / N,N-dimethyl-formamide / 20 °C
2.1: sodium azide; cerium(III) chloride / water; acetonitrile / 72 h / Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / acetonitrile / 5 h
4.1: chloroform / 72 h
5.1: hydrogenchloride; water / methanol / 2 h / 20 °C
6.1: triethylamine / dichloromethane / 20 °C
7.1: triethylamine / N,N-dimethyl-formamide
8.1: hydrazine / ethanol; dichloromethane / 2 h
8.2: 2 h / 20 °C
9.1: 1,2-dichloro-benzene / 72 h / 20 - 120 °C
10.1: water; acetic acid / methanol / 504 h / 50 - 55 °C
With
hydrogenchloride; sodium azide; cerium(III) chloride; water; hydrogen; acetic acid; triethylamine; hydrazine;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogen / palladium 10% on activated carbon / acetonitrile / 5 h
2.1: chloroform / 72 h
3.1: hydrogenchloride; water / methanol / 2 h / 20 °C
4.1: triethylamine / dichloromethane / 20 °C
5.1: triethylamine / N,N-dimethyl-formamide
6.1: hydrazine / ethanol; dichloromethane / 2 h
6.2: 2 h / 20 °C
7.1: 1,2-dichloro-benzene / 72 h / 20 - 120 °C
8.1: water; acetic acid / methanol / 504 h / 50 - 55 °C
With
hydrogenchloride; water; hydrogen; acetic acid; triethylamine; hydrazine;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetonitrile;
