tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

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Chemical Name:tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate
CAS No.:1258976-35-0
Molecular Formula:C₂₅H₃₀N₆O₃S
Molecular Weight:494.618
Hs Code.:

Synonyms:tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

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Chemical Property of tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

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Technology Process of tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

There total 10 articles about tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1258975-43-7
2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

: 1258976-35-0
tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 50 ℃; for 2h;

Reference yield: 94.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 2-isopropoxy-5-(5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl)benzonitrile hydrochloride

: 1258976-35-0
tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 50 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 5-(5-bromo-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]-benzonitrile

: 1258976-35-0
tert-butyl 2-(2-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / isopropyl alcohol / 2 h / 100 °C / Inert atmosphere

2: ethanol / 24 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

4: potassium carbonate / acetonitrile / 2 h / 50 °C

With hydrogenchloride; potassium carbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512