2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

Base Information

Chemical Name:2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile
CAS No.:1258975-43-7
Molecular Formula:C₁₉H₂₀N₆OS
Molecular Weight:380.473
Hs Code.:

Synonyms:2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

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Chemical Property of 2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

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Technology Process of 2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

There total 7 articles about 2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258976-18-9
5-(5-hydrazino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)-oxy]benzonitrile

: 1258975-43-7
2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 1258440-55-9
5-(5-amino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]benzonitrile

: 1258975-43-7
2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 - 70 °C

2: hydrazine hydrate / isopropyl alcohol / 2 h / 100 °C / Inert atmosphere

3: ethanol / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With tert.-butylnitrite; hydrazine hydrate; trifluoroacetic acid; copper(ll) bromide; In ethanol; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 5-(5-bromo-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]-benzonitrile

: 1258975-43-7
2-[(1-methylethyl)oxy]-5-[5-(3-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)-1,3,4-thiadiazol-2-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / isopropyl alcohol / 2 h / 100 °C / Inert atmosphere

2: ethanol / 24 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrazine hydrate; trifluoroacetic acid; In ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.5b01512