2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

Base Information

Chemical Name:2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole
CAS No.:1289563-54-7
Molecular Formula:C₂₇H₃₄INO₃Si
Molecular Weight:575.562
Hs Code.:

Synonyms:2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

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Chemical Property of 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

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Technology Process of 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

There total 10 articles about 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1289563-32-1
2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole

: 1289563-54-7
2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

Guidance literature:: 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

With iodine; In tetrahydrofuran; for 0.0833333h;
DOI:10.1021/jm101597x

Reference yield:

: 1289563-30-9
(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(oxazol-2-yl)methanol

: 1289563-54-7
2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.2: 0.08 h

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1289563-28-5
6-(benzyloxy)-1,2,3,4-tetrahydronaphthalene-2-carboxaldehyde

: 1289563-54-7
2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)-5-iodooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

1.2: 0.67 h / -78 °C

1.3: 2 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

3.2: 0.08 h

With 1H-imidazole; n-butyllithium; borane-THF; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x