4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

Base Information

Chemical Name:4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide
CAS No.:1008764-28-0
Molecular Formula:C₂₄H₂₃FN₄O₃
Molecular Weight:434.47
Hs Code.:

Synonyms:4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

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Chemical Property of 4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

Chemical Property:

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Technology Process of 4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

There total 4 articles about 4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1008764-26-8
4-(3-hydroxybenzoyl)-N-pyridin-3-ylpiperazine-1-carboxamide

: 446-51-5
2-fluorobenzyl alcohol

: 1008764-28-0
4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃;

Reference yield:

: 1008763-98-1
4-[3-(benzyloxy)benzoyl]-N-pyridin-3-ylpiperazine-1-carboxamide

: 1008764-28-0
4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: piperazine-1-carboxylic acid pyridin-3-ylamide bis-hydrochloride salt

: 1008764-28-0
4-{3-[(2-fluorobenzyl)oxy]benzoyl}-N-pyridin-3-ylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 5 h

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;