N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

Base Information

Chemical Name:N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine
CAS No.:128972-08-7
Molecular Formula:C₁₉H₂₄N₄O₃
Molecular Weight:356.425
Hs Code.:

Synonyms:N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

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Chemical Property of N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

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Technology Process of N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

There total 6 articles about N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 128972-04-3
2-hydrazino-3-isobutyl-5-phenylpyrazine

: 36239-09-5
ethyl chlorocarbonylacetate

: 128972-08-7
N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

Guidance literature:: In ethyl acetate; at 0 ℃; for 1h;
DOI:10.1021/jm00171a005

Reference yield:

: 5468-37-1
2-aminoacetophenone hydrochloride

: 128972-08-7
N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1,3-dicyclohexylcarbodiimide (DCC), 2.) 1-hydroxybenzotriazole hydrate (HOBT) / CH₂Cl₂

2: 67 percent / ammonium acetate / ethanol / 3.5 h / Heating

3: COCl₂ / toluene; tetrahydrofuran / 4 h / Heating

4: 45 percent / H₂N-NH₂*H₂O / dimethylsulfoxide / 2 h / Heating

5: 52 percent / ethyl acetate / 1 h / 0 °C

With ammonium acetate; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jm00171a005

Reference yield:

: 128972-06-5
2-chloro-3-isobutyl-5-phenylpyrazine

: 128972-08-7
N-<<(ethoxycarbonyl)methylene>carbonyl>-N'-(3-isobutyl-5-phenylpyrazin-2-yl)hydrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / H₂N-NH₂*H₂O / dimethylsulfoxide / 2 h / Heating

2: 52 percent / ethyl acetate / 1 h / 0 °C

With hydrazine hydrate; In dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm00171a005